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Father and Son Playing

Our Focus

Problem: Bacterial Dysentery
Unmet Global Medical Need, $Billions of Economic Burden

Diarrheal deaths due to the four main bacterial pathogens:

Shigella, Campylobacter, Salmonella & ETEC

440,000

Deaths (annually)

Source: WHO

170,000

Deaths in children (<5s)

Source: WHO

130,000

Deaths in elderly (<70s)

Source: WHO

Bacterial dysentery is a killer

Similar to seasonal influenza (290K – 650K) and malaria (400K) according to WHO

Bacterial Dysentery:
Unpacking the Problem

Sources

  • Bad food

  • Dirty water, flooding

  • Proximity to livestock

Impacts

  • Education

  • Work

  • Life

Characteristics

  • Bloody diarrhea, kidney failutre, etc..

  • Multiple co-infections

  • Lifelong health problems

Treatments

  • Rehydration

  • Antibiotics

  • Vaccines (very few)

Antibiotic resistance is driving need for a break-through vaccine

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